Bullous pemphigoid evolving into cicatricial pemphigoid?

Authors: BANFIELD, C.C.1; PAPADAVID, E.1; FRITH, P.2; ALLEN, J.1; WOJNAROWSKA, F.T.1

Source: Clinical & Experimental Dermatology, Volume 22, Number 1, January 1997 , pp. 30-33(4)

Publisher: Blackwell Publishing

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Abstract:

We describe three patients who initially presented with both clinical and immunological findings to support a diagnosis of bullous pemphigoid but whose subsequent course has been that of cicatricial pemphigoid. Mucosal scarring was accompanied by a fall in autoantibody titres in our three patients. These cases illustrate the difficulties clinicians may experience in assigning a specific diagnosis to patients. They also support the concept that bullous pemphigoid and cicatricial pemphigoid are part of a single disease spectrum. The most intriguing question is what specific factors determine the expression of a particular disease phenotype as bullous pemphigoid and cicatricial pemphigoid share target antigens and also the DQ7 allele.

Document Type: Research article

DOI: 10.1046/j.1365-2230.1997.d01-234.x

Affiliations: 1: Department of Dermatology, The Churchill Hospital, Old Road, Headington, Oxford OX3 7LJ, 2: Department of Ophthalmology, Radcliffe Infirmary, Woodstock Road, Oxford OX2 6HE, UK

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