Endothelial cell activation in cutaneous vasculitis

Authors: JURD, K.M.¹; STEPHENS, C.J.M.; BLACK, M.M.; HUNT, B.J.

Source: Clinical & Experimental Dermatology, Volume 21, Number 1, January 1996 , pp. 28-32(5)

Publisher: Blackwell Publishing

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Abstract:

Markers of endothelial cell activation were measured in 28 patients presenting with various forms of limited or focal type cutaneous vasculitis. Plasma levels of tissue plasminogen activator antigen (t-PA : Ag), plasminogen activator inhibitor type 1 antigen (PAI-1 : Ag) and PAI-1 activity, fibrin plate, von Willebrand factor antigen (vWF : Ag), tissue factor (TF) and soluble thrombomodulin (sTM) were measured. In comparison with the control group (n = 20) there was a significant increase in t-PA : Ag, vWF : Ag and TF (P < 0.05, Mann- Whitney U-test) in the cutaneous vasculitis group. This study confirms that measurable degrees of endothelial activation occur in cutaneous vasculitis.

Document Type: Research article

DOI: 10.1046/j.1365-2230.1996.d01-165.x

Affiliations: 1: Department of Haematology and

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