IngentaConnect Clinical manifestations in 100 Japanese bullous pemphigoid cases ...

Authors: TANAKA, M.¹; HASHIMOTO, T.¹; DYKES, P.J.²; NISHIKAWA, T.¹

Source: Clinical & Experimental Dermatology, Volume 21, Number 1, January 1996 , pp. 23-27(5)

Abstract:

The relationship between clinical findings and antigen profiles in 100 bullous pemphigoid (BP) patients has been investigated. The patients were divided into four groups based upon the results of immunoblot analysis, namely patients whose sera detected the 230-kDa BP antigen (BP230) and the 180-kDa BP antigen (BP180), those recognizing either BP230 or BP180 alone, and those recognizing neither antigen. Analysis by the chi-squared test showed predominant occurrence of oral (P < 0.05) and facial lesions (P < 0.005) in patients whose sera detected BP180, and these patients also tended to have more extensive lesions (P < 0.005). Patients that were positive for BP180 alone needed treatment with higher doses of steroids than the patients positive for BP230 alone (P < 0.05). Furthermore, all five recalcitrant cases, which did not respond well to steroid treatment, were shown to possess autoantibodies against BP180 in their sera. Patients with antibodies to BP230 had a tendency to have a high titre of anti-BMZ antibodies (P < 0.005). These results suggest that anti-BP180 antibodies may be more related to the disease severity than anti-BP230 antibodies.

Document Type: Research article

DOI: 10.1046/j.1365-2230.1996.d01-173.x

Affiliations: 1: Department of Dermatology, Keio University School of Medicine, Tokyo, Japan, 2: University of Wales College of Medicine, Cardiff, UK

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Clinical manifestations in 100 Japanese bullous pemphigoid cases in relation to autoantigen profiles