IngentaConnect Occupational asthma caused by triglycidyl isocyanurate (TGIC)

Authors: PIIRILÄ, P.¹; ESTLANDER, T.¹; KESKINEN, H.¹; JOLANKI, R.¹; LAAKKONEN, A.¹; PFÄFFLI, P.²; TUPASELA, O.¹; TUPPURAINEN, M.¹; NORDMAN, H.¹

Source: Clinical & Experimental Allergy, Volume 27, Number 5, May 1997 , pp. 510-514(5)

Publisher: Blackwell Publishing

Abstract:

Background Polyester powder paints are extensively used in metal painting. Triglycidyl isocyanurate (TGIC), an epoxy compound, is often used as a hardener. Several cases of allergic eczema from occupational exposure to TGIC have been reported in the literature. Objective We examined a 36-year-old non-smoking man who worked mainly as a spray painter, using a polyester powder paint containing 4% TGIC. During painting he used protective clothing and a motorized breathing protector. After 4 years he developed eczema on his hands, face and body, and an occupational allergic eczema caused by TGIC was diagnosed. He also suffered from powder-paint-related asthmatic symptoms. Methods Occupational asthma was diagnosed in accordance with the accepted guidelines. Inhalation challenge tests were performed with the paint and TGIC. Results Spirometry showed slight obstruction; the blood eosinophils and serum IgE value were elevated. Skin-prick tests with common environmental allergens were negative. The challenge test with lactose powder was also negative. A challenge test with a paint containing TGIC (4%) induced a dual reaction in PEF and a late 23% fall in FEV₁. A test with TGIC (4%) mixed with lactose induced a dual PEF reaction, and also dual changes in spirometry. The PD₁₅ in the histamine challenge test decreased significantly after the challenge tests. Conclusions To our knowledge this is the first diagnosed case of occupational asthma caused by TGIC. This case report emphasizes the importance of protecting both the skin and respiratory tract of workers against chemicals such as TGIC, capable of causing skin and respiratory allergy.

Keywords: polyester powder paints; occupational asthma; contact dermatitis; triglycidyl isocyanurate (TGIC); epoxy

Document Type: Research article

DOI: 10.1046/j.1365-2222.1997.350858.x

Affiliations: 1: Departments of Occupational Medicine, 2: Industrial Hygiene and Toxicology, Finnish Institute of Occupational Health, Helsinki, Finland

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