Polycystic ovary syndrome and pregnancy outcome: red herring or red flag?

Authors: Siassakos; Wardle1

Source: BJOG: An International Journal of Obstetrics & Gynaecology, Volume 114, Number 8, August 2007 , pp. 922-932(11)

Publisher: Blackwell Publishing

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Abstract:

Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in women, associated with a characteristic ovarian appearance at ultrasound scan, hyperandrogenism, and ovulatory disorders. The pathogenesis appears to be mainly related to reduced insulin sensitivity in peripheral tissues, leading to hyperinsulinaemia. There is a wide variation in the severity of PCOS symptoms. Women with PCOS are believed to be predisposed to a variety of complications in pregnancy. We present a summary of the evidence surrounding these claims and discuss the weaknesses of the available to date studies.

Keywords: EPL; insulin; outcome; PCOS; pregnancy

Document Type: Research article

DOI: 10.1111/j.1471-0528.2007.01418.x

Affiliations: 1: Department of Obstetrics and Gynaecology, Fertility clinic, Cotswold Centre, Southmead Hospital, North Bristol NHS Trust, Bristol, UK

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