The relationship between the onset of electrographic seizure activity after birth and the time of cerebral injury in utero

Authors: Filan, P.1; Boylan, G.B.2; Chorley, G.1; Davies, A.1; Fox, G.F.3; Pressler, R.1; Rennie, J.M.1

Source: BJOG: An International Journal of Obstetrics & Gynaecology, Volume 112, Number 4, April 2005 , pp. 504-507(4)

Publisher: Blackwell Publishing

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Abstract:

In the fetal lamb model of hypoxic–ischaemic injury, the insult is followed by EEG depression, after which seizures emerge at 7–13 hours. We explored the relationship between the emergence of electrographic seizures and our estimate of the time of the cerebral injury in nine babies who underwent continuous video-EEG monitoring from soon after birth. Babies with prelabour insults had their first seizures before 12 hours of age, whereas those whose insult was peripartum had seizure onset at 18–20 hours of age. EEG seizure onset time could have important clinical and medico-legal applications, and be related to the time or severity of the insult, or both.

Document Type: Short communication

DOI: 10.1111/j.1471-0528.2004.00476.x

Affiliations: 1: Neonatal Intensive Care Unit, Nightingale Birth Centre and Department of Neurophysiology, King's College Hospital, London, UK 2: Department of Paediatrics and Child Health, Cork University Hospital, Ireland 3: Neonatal Intensive Care Unit, St Thomas' Hospital, London, UK

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