IngentaConnect Fetal bone metabolism in normal and rhesus isoimmunised pregnanci...

Authors: Ogueh, Onome¹; Wright, Eileen M.²; Jones, Julia³; Alaghband-Zadeh, Jamshid³; Nicolaides, Kypros H.⁴; Johnson, Mark Richard¹

Source: BJOG: An International Journal of Obstetrics & Gynaecology, Volume 108, Number 9, September 2001 , pp. 986-992(7)

Publisher: Blackwell Publishing

Abstract:

Objective

To construct gestation-specific reference intervals for fetal concentrations of biochemical markers of bone metabolism and assess the effect of rhesus isoimmunisation on these. Methods

Fetal blood samples were obtained by cordocentesis from 175 pregnancies (43 complicated by rhesus isoimmunisation) and assayed for carboxy terminal pro-peptide of type I pro-collagen (PICP) and cross-linked carboxyterminal telopeptide of type I collagen (ICTP) which directly monitor the rate of bone formation and resorption respectively. Results

Both plasma PICP and ICTP were negatively correlated with gestational age (r =−0.351 and−0.472 for PICP and ICTP, respectively, and P<0.001 for both). In fetuses affected by rhesus isoimmunisation PICP levels were lower ( P=0.030 ) and more variable ( P <0.001 ) than expected, compared with normal unaffected fetuses. However, no such differences were found in the ICTP levels. In the fetuses affected by rhesus isoimmunisation there was a significant correlation between haemoglobin concentration and both PICP ( r = 0.504, P= 0.001 ) and ICTP ( r = 0.343, P= 0.030 ). Conclusions

Fetal bone turnover declines from early second trimester to term, and may be deranged in fetuses affected by rhesus isoimmunisation.

Document Type: Research article

DOI: 10.1111/j.1471-0528.2001.00219.x

Affiliations: 1: Department of Maternal and Fetal Medicine, Chelsea and Westminster Hospital, London, UK 2: Department of Medical Statistics and Evaluation, Hammersmith Hospital, London, UK 3: Department of Chemical Pathology, Charing Cross Hospital and Imperial College School of Medicine, London, UK 4: Harris Birthright Research Centre for Fetal Medicine, King's College Hospital, London, UK

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Fetal bone metabolism in normal and rhesus isoimmunised pregnancies