Ocular adnexal lymphoma: no evidence for bacterial DNA associated with lymphoma pathogenesis

Authors: Matthews, Julie M.; Moreno, Lilliana I.; Dennis, Jeremy¹; Byrne, Gerald E.²; Ruiz, Phillip²; Dubovy, Sander R.; Lossos, Izidore S.

Source: British Journal of Haematology, Volume 142, Number 2, July 2008 , pp. 246-249(4)

Publisher: Blackwell Publishing

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Abstract:

Summary

Ocular Adnexal Lymphomas (OALs) are the most common tumors of the eye, the majority being extranodal mucosa-associated lymphoid tissue (MALT) lymphomas. Association with Chlamydia psittaci was described in some geographic areas. OAL response to antibiotic therapy was reported in cases not harboring Chlamydia psittaci DNA, suggesting that other bacterial infection might be implicated in the pathogenesis. We examined 49 MALT OALs for bacterial DNA using two distinct polymerase chain reaction techniques based on universal bacterial primers. No bacterial DNA that could be implicated in OAL pathogenesis was detected, suggesting that bacterial infection is not associated with OAL in South Florida.

Keywords: ocular adnexal lymphoma; MALT; Chlamydia

Document Type: Research article

DOI: 10.1111/j.1365-2141.2008.07112.x

Affiliations: 1: Sylvester Comprehensive Cancer Center, Division of Hematology-Oncology, Department of Medicine, University of Miami 2: Department of Pathology, University of Miami

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