Cyclophosphamide and antithymocyte globulin as a conditioning regimen for allogeneic marrow transplantation in patients with aplastic anaemia: a long-term follow-up

Authors: Kahl, Christoph¹; Leisenring, Wendy; Joachim Deeg, H.; Chauncey, Thomas R.; Flowers, Mary E. D.; Martin, Paul J.; Sanders, Jean E.; Storb, Rainer

Source: British Journal of Haematology, Volume 130, Number 5, September 2005 , pp. 747-751(5)

Publisher: Blackwell Publishing

Key:

- Free Content

- New Content

- Subscribed Content

- Free Trial Content

Abstract:

Summary

A total of 81 severe aplastic anaemia patients, aged 2–63 years, received human leucocyte antigen-matched related marrow grafts after cyclophosphamide + antithymocyte globulin followed by postgrafting methotrexate + ciclosporin. Median follow-up was 9·2 years. Ninety-six per cent of patients had sustained engraftment, 24% developed acute graft-versus-host disease (GVHD), grade II in all but two patients, and 26% developed chronic GVHD; all surviving patients eventually responded to immunosuppressive therapy. Six patients developed cancer: one fatal lymphoma and five carcinomas (all five patients are now free of cancer). Survival was 88%. The regimen appeared well tolerated and effective in heavily pretreated patients with aplastic anaemia.

Keywords: aplastic anaemia; human leucocyte antigen-matched marrow grafts; cyclophosphamide/antithymocyte globulin conditioni

Document Type: Research article

DOI: 10.1111/j.1365-2141.2005.05667.x

Affiliations: 1: Clinical Research Division, Fred Hutchinson Cancer Research Center

The full text electronic article is available for purchase. You will be able to download the full text electronic article after payment.

$50.16 plus tax Refund Policy