IngentaConnect Superior mobilisation of haematopoietic progenitor cells with gly...

Authors: Fischer, Johannes C.; Frick, Markus; Wassmuth, Ralf; Platz, Alexander; Punzel, Michael; Wernet, Peter

Source: British Journal of Haematology, Volume 130, Number 5, September 2005 , pp. 740-746(7)

Abstract:

Summary

Granulocyte colony-stimulating factor (G-CSF) effectively mobilises haematopoietic stem cells to the peripheral blood. It is unclear whether the mobilisation of stem cells with lenograstim (glycosylated G-CSF) or filgrastim (non-glycosylated G-CSF) leads to a higher cell number of collected engraft able progenitor cells. Thus, we investigated harvesting efficiency of the licensed G-CSF preparations in mobilising peripheral stem cells in a randomised study. A total of 501 healthy unrelated donors, including 339 males and 162 females received either lenograstim (n = 261) or filgrastim (n = 240) at 10 g/kg body weight (BW) per day. Aphaeresis was performed on day 5 and, if necessary, on day 6 of mobilisation. The number of CD34⁺ cells collected was 11·5% higher in the lenograstim group (7·19 × 10⁶ vs. 6·44 × 10⁶/kg BW donor; P < 0·03). Univariate variance analysis revealed that this effect was caused by male donors: more progenitors cells per kg BW of the donor (7·73 × 10⁶ vs. 6·88 × 10⁶; P < 0·017) and of the recipient (10·1 × 10⁶ vs. 8·88 × 10⁶, P < 0·029) could be harvested. There was no significant difference in the percentage of donors in whom a second aphaeresis was required (9·6% vs. 11·6%). Lenograstim mobilises progenitor cells into the peripheral blood more effectively in males than filgrastim.

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Superior mobilisation of haematopoietic progenitor cells with glycosylated G-CSF in male but not female unrelated stem cell donors