IngentaConnect Comparative genomic hybridisation identifies two variants of smol...

Authors: Rosiñol, Laura¹; Carrió, Ana²; Bladé, Joan¹; Queralt, Rosa²; Aymerich, Marta²; Cibeira, MaTeresa¹; Esteve, Jordi¹; Rozman, Maria²; Campo, Elías²; Montserrat, Emili¹

Source: British Journal of Haematology, Volume 130, Number 5, September 2005 , pp. 729-732(4)

Publisher: Blackwell Publishing

Abstract:

Summary

Two variants of smoldering multiple myeloma (SMM) have been recognised: (i) an evolving type, characterised by a progressive increase in the M-protein size and short time to progression to overt multiple myeloma (MM) and (ii) a non-evolving type, with a long-lasting, stable M-protein and longer time to progression. Comparative genomic hybridisation (CGH) analyses in both subtypes of SMM (seven evolving and eight non-evolving SMM) were performed. Evolving SMM showed cytogenetic changes consistent with those found in de novo symptomatic MM (1q gains, chromosome 13 deletions) while the non-evolving variant showed no 1q gains and deletions were uncommon.

Keywords: smoldering multiple myeloma; comparative genomic hybridisation; multiple myeloma; prognosis; transformation

Document Type: Research article

DOI: 10.1111/j.1365-2141.2005.05673.x

Affiliations: 1: Haematology Department, Institute of Haematology and Oncology, Institut d'Investigacions Biomèdiques Agustí Pi i Sunyer (IDIBAPS), Hospital Clinic, University of Barcelona, Barcelona 2: Haematopathology Department, Institut d'Investigacions Biomèdiques Agustí Pi i Sunyer (IDIBAPS), Hospital Clinic, University of Barcelona, Barcelona, Spain

The full text electronic article is available for purchase. You will be able to download the full text electronic article after payment.

$50.39 plus tax Refund Policy

Comparative genomic hybridisation identifies two variants of smoldering multiple myeloma