A CD4+ proliferation of large granular lymphocytes expresses the protease activated receptor-1
Authors: Macey1; Hou2; Milne1; Parameswaren1; Howe3; Cavenagh1; Howells2; Newland1
Source: British Journal of Haematology, Volume 101, Number 1, April 1998 , pp. 78-81(4)
Publisher: Blackwell Publishing
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Abstract:
The platelet-type thrombin receptor was the first member to be identified in a family of protease activated receptors (PARs) and has been designated PAR-1. We recently reported that the large granular lymphocytes (LGLs) in patients with proliferations of CD8+ cells co-expressed PAR-1 and the expression of PAR-1 correlated with the expression of CD57. Here we show, by three-colour immunofluorescence, that the LGLs from a patient with a rare CD4+ CD57+ monoclonal expansion also expressed PAR-1. Northern blot analysis confirmed the presence of high levels of mRNA for PAR-1 in these LGLs.Keywords: protease-activated receptor-1; large granular lymphocytes; CD4
Document Type: Research article
DOI: 10.1046/j.1365-2141.1998.00673.x
Affiliations: 1: Department of Haematology, The Royal London Hospital, Whitechapel, London, 2: Department of Oral Pathology, The Royal London Hospital School of Medicine and Dentistry, London, 3: Leukaemia Research Laboratory, Taunton and Somerset NHS Trust, Musgrove Park Hospital, Taunton, Somerset
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