CD3−CD4−CD8−CD56−CD19−CD14− cells and CD3+CD8 dull-positive cells produce IL-4 in AIDS patients

Authors: Honda, Junichi1; Okubo, Yasumitsu1; Tanaka, Ken1; Kusaba, Mikako1; Kumagai, Mutsuko1; Saruwatari, Naoko1; Oizumi, Kotaro1

Source: British Journal of Haematology, Volume 101, Number 1, April 1998 , pp. 74-77(4)

Publisher: Blackwell Publishing

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Abstract:

We used flow cytometry to identify the presence of intracellular cytokines (cytoflow) and analyse the production of IL-4 in peripheral blood from AIDS patients who have practically no CD4+ T cells. We found that IL-4 was produced by CD3−CD4−CD8−CD56−CD19−CD14− cells and CD3+CD8 dull-positive cells in AIDS patients. Moreover, CD3−CD4− CD8−CD56−CD19−CD14− cells had helper activity for immunoglobulin synthesis. These findings indicate that instead of CD4+ T helper cells, C3−CD4−CD8−CD56− CD19−CD14− cells and CD3+CD8 dull-positive cells may be an important source of IL-4 in a variety of immune responses for AIDS patients.

Keywords: HIV, CD4, IL-4, Th1, Th2

Document Type: Research article

DOI: 10.1046/j.1365-2141.1998.00647.x

Affiliations: 1: First Department of Internal Medicine, Kurume University School of Medicine, Kurume, Fukuoka, Japan

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