The Platelet Function Analyzer (PFA-100®): a novel in-vitro system for evaluation of primary haemostasis in children
Authors: Carcao1; Blanchette1; Dean1; He1; Kern1; Stain1; Sparling2; Stephens3; Ryan4; Freedman5; Rand1
Source: British Journal of Haematology, Volume 101, Number 1, April 1998 , pp. 70-73(4)
Publisher: Blackwell Publishing
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Abstract:
The PFA-100® system provides an in-vitro method of assessing primary platelet-related haemostasis by measuring the time (the closure time, or CT) taken for a platelet plug to occlude a microscopic aperture cut into a membrane coated with collagen and either epinephrine or ADP. We used the system to establish normal ranges for CTs in healthy children, adults and neonates. Mean CTs of healthy children were independent of the needle gauge used (21G or 23G) for blood sampling; they were very similar to the mean CTs of healthy adults, but longer than mean CTs of healthy neonates. Although children with haemophilia had normal CTs, the PFA-100 system was found to be potentially useful in screening for von Willebrand disease in children.Keywords: platelet function; primary haemostasis; PFA-100®; bleeding time; von Willebrand disease
Document Type: Research article
DOI: 10.1046/j.1365-2141.1998.00656.x
Affiliations: 1: Divisions of Haematology/Oncology, 2: Department of Paediatric Laboratory Medicine, The Hospital for Sick Children, 3: Clinical Epidemiology, Department of Paediatrics, 4: Division of Perinatology, Mount Sinai Hospital, 5: Division of Haematology, St Michael's Hospital, Departments of,
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