IngentaConnect Onychomycosis caused by Fusarium proliferatum

Authors: Hattori, N.; Shirai, A.; Sugiura, Y.¹; Li, W.²; Yokoyama, K.³; Misawa, Y.⁴; Okuzumi, K.⁴; Tamaki, K.

Source: British Journal of Dermatology, Volume 153, Number 3, September 2005 , pp. 647-649(3)

Abstract:

Summary

Fusarium infections in humans are usually opportunistic, but the fungus sometimes infects healthy persons, causing keratomycosis or onychomycosis. Onychomycosis is usually caused by F. solani or F. oxysporum. We report the first two cases of onychomycosis caused by F. proliferatum, and discuss methods of diagnosis and effective treatment. Nail samples from the two patients were examined by direct microscopy, cultured, and identified morphologically and genetically as F. proliferatum. Both patients were treated successfully with oral itraconazole, even though the minimum inhibitory concentration of itraconazole was relatively high in Patient 1. This is the first report of F. proliferatum as an agent of onychomycosis. Itraconazole may be effective in the treatment of onychomycosis caused by F. proliferatum.

Keywords: onychomycosis; Fusarium proliferatum; itraconazole; cytochrome 011011011011011b

Document Type: Research article

DOI: 10.1111/j.1365-2133.2005.06692.x

Affiliations: 1: Kobe Institute of Health, Kobe, Japan, 2: Department of Pathogen Biology, School of Basic Medical Science, Norman Bethune Medical Division of Jilin University, China, 3: Chiba University Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba, Japan, 4: Department of Infection Control and Prevention, Faculty of Medicine, University of Tokyo, Tokyo, Japan

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