Gemcitabine-associated CD8+ CD30+ pseudolymphoma

Authors: Marucci G.; Sgarbanti E.1; Maestri A.2; Calandri C.2; Collina G.

Source: British Journal of Dermatology, Volume 145, Number 4, October 2001 , pp. 650-652(3)

Publisher: Blackwell Publishing

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Abstract:

We describe a 69-year-old man with a non-small cell carcinoma of the lung, stage III B, who developed bilateral multiple erythematous lesions in the abdominal–inguinal area following treatment with gemcitabine. Histologically, the lesion was characterized by a heavy lymphocytic infiltrate with large CD30+ cells. The lesion was highly suggestive of cutaneous involvement by malignant lymphoma, but complete regression was observed after cessation of gemcitabine. Although rarely reported, gemcitabine therapy can induce skin lesions. Pathologists should be aware of this possibility in order to avoid a misdiagnosis.

Keywords: CD30; cutaneous disease; gemcitabine; lymphoproliferative reaction

Document Type: Research article

DOI: 10.1046/j.1365-2133.2001.t01-1-04461.x

Affiliations: 1: Service of Dermatology, University of Bologna, Bellaria Hospital, via Altura 3, 40139 Bologna, Italy 2: Oncology, Department of Oncology, and

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