Evidence for loss of heterozygosity in human psoriatic lesions
Authors: Zachos1; Koumantaki2; Vareltzidis3; Spandidos1
Source: British Journal of Dermatology, Volume 139, Number 6, December 1998 , pp. 974-977(4)
Publisher: Blackwell Publishing
- Free Content
- New Content
- Subscribed Content
- Free Trial Content
Abstract:
Psoriasis, a disease of human skin, is characterized by abnormal differentiation and hyperproliferation of keratinocytes; it has a genetic background. Using 11 highly polymorphic microsatellite markers on eight chromosome arms, we performed an allelotype analysis in 14 psoriatic plaques, in order to reveal any chromosome deletions involved in the development of the disease. We detected loss of heterozygosity (LOH) on at least one microsatellite marker in nine of 14 (64%) cases. We also observed particular genetic loci altered with LOH, on chromosomes 3p, 7p/q and 8p. Our results suggest that LOH is an important phenomenon in the development of psoriatic plaques, providing evidence for deletion of regulatory genes.Document Type: Original article
DOI: 10.1046/j.1365-2133.1998.02551.x
Affiliations: 1: Institute of Biological Research and Biotechnology, National Hellenic Research Foundation, 48 Vas. Constantinou Ave, Athens 11635, Greece, 2: Division of Virology, Medical School, University of Crete, Heraklion, 71409, Greece, 3: Medical School, University of Athens, Department of Dermatology, `A. Sygros' Hospital, Athens, Greece
- Free Content
- New Content
- Subscribed Content
- Free Trial Content
Click here for Page Help