@article {SHYU:October 1996:0306-5251:513,
	author = "SHYU, W. C.",
	author = "BARBHAIYA, R. H.",
	title = "Lack of pharmacokinetic interaction between butorphanol nasal spray and cimetidine",
	journal = "British Journal of Clinical Pharmacology",
	volume = "42",
	year = "October 1996",
	abstract = "The potential for a pharmacokinetic interaction between butorphanol nasal spray and cimetidine, under steady state conditions, was evaluated in 16 healthy male volunteers. Subjects received either a 1&#8195;mg butorphanol nasal spray every 6&#8195;h or a 300&#8195;mg cimetidine tablet every 6&#8195;h on days 1-4, the combination of two compounds every 6&#8195;h on days 5-8 and the original treatment as described in the first segment (days 1-4) on days 9-12. Serial blood and urine samples were collected on days 4, 8 and 12, and additional blood samples were taken immediately, prior to the morning dose on days 3, 7 and 11. Based on the analysis of the <I>C</I><SUB>min</SUB> samples, the plasma concentrations of cimetidine and butorphanol achieved steady state by the third day of dosing. No statistically significant differences were found in the plasma concentrations of butorphanol or cimetidine (except for <I>t</I><SUB>&#189;</SUB> and MRT) between any of the treatment phases. Butorphanol nasal spray and cimetidine can be co-administered without any adjustment of dosage for either drug.",
	pages = "513-517(5)",
	url = "http://www.ingentaconnect.com/content/bsc/bjcp/1996/00000042/00000004/art00017"
	doi = "doi:10.1046/j.1365-2125.1996.459/2.x"
}