Structure of Escherichia coli YfdW, a type III CoA transferase

Authors: Gogos, Arhonda; Gorman, Jason; Shapiro, Lawrence

Source: Acta Crystallographica Section D, Volume 60, Number 3, March 2004 , pp. 507-511(5)

Publisher: Blackwell Publishing

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Abstract:

Crystal structures are reported for free and coenzyme A (CoA) bound forms of the YfdW protein from Escherichia coli, a representative type III CoA transferase. The structures reveal a two-domain protomer with interdomain connections forming a ring-like structure with a large central hole. Two protomers associate to form a highly intertwined dimer in which the hole of each ring is filled by the partner molecule. Each protomer binds a single CoA molecule and these CoA-binding sites are distant from one another in the dimer.

Keywords: structural genomics; type III CoA transferase; intertwined dimer

Document Type: Research article

DOI: 10.1107/S0907444904000034

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