Partitioning of genetic values associated with identified genotype and residual genotype

Author: LIN, Ching Y.1

Source: Animal Science Journal, Volume 73, Number 4, August 2002 , pp. 263-268(6)

Publisher: Blackwell Publishing

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Abstract:

A simplified partition procedure was developed to partition the genetic value associated with the identified genotype (a combined genotype of all quantitative trait loci (QTL) identified) and residual genotype. The simplified partition procedure does not require the construction of mixed model equations for both identified and residual genotypes, and therefore drastically reduces the computing requirements as compared with the direct partition procedure. Both the simplified and the direct partition procedures were shown to be equivalent theoretically and experimentally. The simplified partition procedure also applies to the partitioning of other random effects such as the partition of sire effect into two components (constant and interaction sire effects) without actually solving the mixed model equations of the partitioned sire model. The relative contribution of the identified loci and the residual genotypes to the genetic value of a trait depends on their correlation (ρqr) and the ratio of their genetic variances (σ2q/σ2r). Identifying more QTL or increasing QTL variance would add to the contribution of identified QTL to the total genetic value of a quantitative trait. However, the additional contribution of identifying each extra QTL increases at a decreasing rate when the correlation between identified and residual genotypes is positive, but at an increasing rate when the correlation is negative. An effective QTL-assisted selection program should consider both direct and associated effects of the identified loci.

Keywords: identified genotype; partitioning; residual genotype

Document Type: Research article

DOI: 10.1046/j.1344-3941.2002.00036.x

Affiliations: 1: Dairy and Swine Research and Development Center, Agriculture and Agri-Food Canada

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