IngentaConnect Posttransplant lymphoproliferative disorder: A pictorial review

Authors: Burney; Bradley; Buckley; Lyburn; Rye; Hopkins

Source: Australasian Radiology, Volume 50, Number 5, October 2006 , pp. 412-418(7)

Abstract:

Summary

Posttransplant lymphoproliferative disorder (PTLD) is a serious and potentially fatal complication after solid organ and haemopoietic stem cell transplantation. The frequency of PTLD varies with the type of organ transplant but overall it affects 2-10% of all solid organ transplant recipients. Most cases develop within 1 year after the transplant, although occasional cases present 5-10 years later. Posttransplant lymphoproliferative disorder is clinically and pathologically heterogeneous - the majority are of the non-Hodgkin's lymphoma type, whereas Hodgkin's lymphoma arising after transplantation is rare. We have retrospectively reviewed patients with a histological diagnosis of PTLD after a solid organ transplant. We present the imaging features and a clinical review of this condition. Early diagnosis of PTLD may alter the management and outcome of the disease. The radiologist can play a vital role in establishing the diagnosis by imaging features supplemented with percutaneous biopsy and also in monitoring the disease response to treatment.

Keywords: imaging; transplant complications; posttransplant lymphoproliferative disorder

Document Type: Research article

DOI: 10.1111/j.1440-1673.2006.01618.x

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