In vitro study of relationship between signal intensity and gadolinium-DTPA concentration at high magnetic field strength

Authors: Shahbazi-Gahrouei D.; Williams M.; Allen B.

Source: Australasian Radiology, Volume 45, Number 3, August 2001 , pp. 298-304(7)

Publisher: Blackwell Publishing

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Abstract:

SUMMARY

Although gadolinium-diethylene triamine pentaacetic acid (Gd-DTPA) has been used as a contrast material in MRI, it is known that the contrast enhancement effect is not uniform for high concentrations of Gd-DTPA. In order to evaluate the proper pulse sequences for dynamic MRI in aqueous solutions of Gd-DTPA, blood samples and melanoma cells, the signal intensity for several concentrations of Gd-DTPA were measured under inversion recovery (T₁-weighted) at high magnetic field strength (7.0 Tesla). For aqueous solutions of Gd-DTPA, signal intensity correlated linearly with the concentration of Gd-DTPA between 0 mmol/L and 4 mmol/L. Using blood and melanoma cells, signal intensity correlated non-linearly with the concentration of Gd-DTPA between 0 mmol/L and 1.5 mmol/L. For concentrations of more than 4 mmol/L in aqueous solutions of Gd-DTPA, 1 mmol/L in blood and 1.5 mmol/L in melanoma, signal intensity decreased with increased Gd-DTPA concentration.

Keywords: Gd-DTPA; magnetic resonance imaging; melanoma; signal intensity

Language: English

Document Type: Research article

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