Hypertrophic osteoarthropathy: An unusual manifestation in nasopharyngeal cancer

Authors: Biswal, BM¹; Kareem, A²; Ahmed, NM¹

Source: Australasian Radiology, Volume 45, Number 1, February 2001 , pp. 71-73(3)

Publisher: Blackwell Publishing

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Abstract:

SUMMARY

A patient with nasopharyngeal carcinoma developed clubbing and hypertrophic osteoarthropathy 6 months before radiological detection of secondary deposits in the lung. Another patient with nasopharyngeal carcinoma developed digital clubbing and hypertrophic osteoarthropathy 6 months after the discovery of lung metastases. Development of a paraneoplastic syndrome in the form of hypertrophic osteoarthropathy and digital clubbing is very rare. This manifestation of nasopharyngeal cancers is presented, with a short review of its biology and pathogenesis.

Keywords: clubbing; hypertrophic osteoarthropathy; nasopharyngeal cancer; radiotherapy

Document Type: Research article

DOI: 10.1046/j.1440-1673.2001.00883.x

Affiliations: 1: Radiotherapy and Oncology and 2: Radiology, School of Medical Sciences, Universiti Sains Malaysia, Kelantan, Malaysia

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