Strontium-89 treatment for prostate cancer bone metastases: Does a prostate-specific antigen response predict for improved survival?

Authors: Zyskowski, Adam; Lamb, David; Morum, Pauline; Hamilton, David; Johnson, Carol

Source: Australasian Radiology, Volume 45, Number 1, February 2001 , pp. 39-42(4)

Publisher: Blackwell Publishing

Key:

- Free Content

- New Content

- Subscribed Content

- Free Trial Content

Abstract:

SUMMARY

A review of 50 patients treated with strontium-89 for prostate cancer bone metastases from January 1993-1997 at the Wellington Cancer Centre was undertaken to determine if there was any correlation between changes in prostate-specific antigen (PSA) following treatment and subsequent survival. Thirty cases were evaluable for PSA response. Of these, 14 had a fall in PSA following strontium-89 treatment, and their mean survival was 641 days. The remaining 16 patients did not demonstrate a post-treatment fall in PSA and their mean survival was 275 days. A difference between these two groups in the time to development of new bone symptoms following treatment was also observed. No significant correlation between pretreatment PSA and PSA response was observed. In conclusion, a PSA response following strontium-89 treatment appears to predict for improved survival in patients with bone metastases from carcinoma of the prostate. Further prospective studies are indicated.

Keywords: prostate cancer; prostate-specific antigen; strontium-89; survival

Document Type: Research article

DOI: 10.1046/j.1440-1673.2001.00871.x

The full text electronic article is available for purchase. You will be able to download the full text electronic article after payment.

$50.16 plus tax Refund Policy