@article {BUTI:February 2006:0953-0673:409,
	author = "BUTI, M.",
	author = "CASADO, M. A.",
	author = "CALLEJA, J. L.",
	author = "SALMERON, J.",
	author = "AGUILAR, J.",
	author = "RUEDA, M.",
	author = "ESTEBAN, R.",
	title = "Cost-effectiveness analysis of lamivudine and adefovir dipivoxil in the treatment of patients with HBeAg-negative chronic hepatitis B",
	journal = "Alimentary Pharmacology & Therapeutics",
	volume = "23",
	year = "February 2006",
	abstract = "Summary Aim <P></P> To estimate the cost-effectiveness over a 4-year duration of lamivudine and adefovir dipivoxil for patients with hepatitis B `e' antigen-negative chronic hepatitis B. Methods <P></P>A decision analysis model has been used to perform a cost-effectiveness analysis of lamivudine and adefovir dipivoxil from the perspective of the Spanish Public Health System. Data were obtained from clinical trials. Results <P></P>For the base-case, the total estimated cost per patient treated with lamivudine or adefovir dipivoxil for 4&#8201;years was &#8364;11&#8201;457 and &#8364;21&#8201;939 respectively. Virological response at year 4 for the lamivudine arm was 40.4% and 78.0% for the adefovir dipivoxil arm. The average cost-effectiveness ratio (cost per responding patient at year 4) was &#8364;28&#8201;375 for the lamivudine arm and &#8364;28&#8201;132 for the adefovir dipivoxil arm. The incremental cost-effectiveness ratio of adefovir dipivoxil vs. lamivudine (cost per additional responding patient with adefovir dipivoxil) was &#8364;27&#8201;872, demonstrating that this cost was slightly lower than the average cost-effectiveness ratios of adefovir dipivoxil or lamivudine. The sensitivity analysis demonstrated that the factors that most influence the cost-effectiveness were the response to adefovir dipivoxil and lamivudine at year 4. Conclusion <P></P>Long-term treatment with adefovir dipivoxil is a cost-effective strategy in patients with chronic hepatitis B `e' antigen-negative hepatitis.",
	pages = "409-419(11)",
	url = "http://www.ingentaconnect.com/content/bsc/apt/2006/00000023/00000003/art00008"
	doi = "doi:10.1111/j.1365-2036.2006.02767.x"
}