@article {Ortiz:June 2002:0953-0673:1163,
author = "Ortiz, R. A. M.",
author = "Calafatti, S. A.",
author = "Corazzi, A.",
author = "Souza, J. M.",
author = "Deguer, M.",
author = "De Souza, C. A. F.",
author = "Marchioretto, M. A. M.",
author = "Bernasconi, G.",
author = "Ferraz, J. G. P.",
author = "Pedrazzoli, J.",
title = "Amoxicillin and ampicillin are not transferred to gastric juice irrespective of Helicobacter pylori status or acid blockade by omeprazole",
journal = "Alimentary Pharmacology & Therapeutics",
volume = "16",
year = "June 2002",
abstract = "Background: The effects of proton pump inhibitors and Helicobacter pylori infection on the distribution of drugs used for the eradication of the bacteria are poorly understood. Aim: The aim of this study was to investigate the effects of a 7-day administration of 20 mg of omeprazole on the pharmacokinetics of amoxicillin and ampicillin in the plasma, saliva and gastric juice of individuals with and without H. pylori infection. Methods: Fifty-four healthy volunteers without endoscopic lesions were enrolled. Twenty-six volunteers were included in the amoxicillin study and 28 individuals in the ampicillin study. Each study had an open randomized two-period crossover design and a 21-day washout period between phases. Plasma, saliva and gastric juice concentrations of amoxicillin and ampicillin in subjects with and without omeprazole pre-treatment were measured by reversed-phase HPLC using UV detection. Results: Neither pre-treatment with omeprazole nor H. pylori infection interfered with the plasma bioavailability of amoxicillin or ampicillin, as assessed by the AUC0-2 h. Neither ampicillin nor amoxicillin were detected in saliva or gastric juice in any study phase. Conclusion: Short-term treatment with omeprazole does not interfere with the pharmacokinetics of amoxicillin or ampicillin. Our results also exclude the presence of a transfer mechanism for amoxicillin or ampicillin from the plasma to the gastric lumen.",
pages = "1163-1170(8)",
url = "http://www.ingentaconnect.com/content/bsc/apt/2002/00000016/00000006/art00017"
doi = "doi:10.1046/j.1365-2036.2002.01262.x"
}