IngentaConnect Duodenogastric reflux following cholecystectomy in the dog: role ...

Authors: Nogi, K.¹; Haruma, K.²; Taniguchi, H.¹; Yomota, E.¹; Okajima, M.³; Hananoki, M.²; Hata, J.²; Kusunoki, H.²; Onoda, Y.¹

Source: Alimentary Pharmacology & Therapeutics, Volume 15, Number 8, August 2001 , pp. 1233-1238(6)

Publisher: Blackwell Publishing

Abstract:

Background

: Duodenogastric reflux has been implicated in the pathogenesis of gastric ulcer and gastritis. Duodenogastric reflux after cholecystectomy is also a possible cause of post-cholecystectomy syndrome. Aim

: To investigate the role of antroduodenal motor function in increased duodenogastric reflux following cholecystectomy and the effect of trimebutine maleate (trimebutine) on the duodenogastric reflux in conscious dogs. Methods

: Antropyloric and duodenal motility and bile acids content in the gastric juice were measured for 3 h during the inter-digestive state in dogs with or without cholecystectomy. Results

: Bile acids content in the gastric juice of cholecystectomized dogs was significantly higher than that of non-cholecystectomized dogs. The frequency of pyloric relaxation during phase II of the migrating motor complex was significantly increased following cholecystectomy. Intravenous infusion of trimebutine inhibited both the increased duodenogastric reflux and the frequency of pyloric relaxation in the cholecystectomized dog. Conclusion

: Duodenogastric reflux and frequency of pyloric relaxations were increased in cholecystectomized dogs and trimebutine suppressed both of them. These findings suggest that the increased frequency of pyloric relaxation contributes to the duodenogastric reflux following cholecystectomy.

Document Type: Research article

DOI: 10.1046/j.1365-2036.2001.01035.x

Affiliations: 1: Discovery Research Laboratory, Tanabe Seiyaku Co. Ltd, Toda, Saitama, Japan 2: First Department of Internal Medicine, Hiroshima University School of Medicine, Hiroshima, Japan 3: Second Department of Surgery, Hiroshima University School of Medicine, Hiroshima, Japan

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Duodenogastric reflux following cholecystectomy in the dog: role of antroduodenal motor function