IngentaConnect Efficacy of ecabet sodium for Helicobacter pylori eradication tri...

Authors: Adachi, K.¹; Ishihara, S.¹; Hashimoto, T.²; Hirakawa, K.³; Ishimura, N.¹; Niigaki, M.³; Kaji, T.³; Kawamura, A.¹; Sato, H.¹; Fujishiro, H.¹; Hattori, S.²; Watanabe, M.¹; Kinoshita, Y.¹

Source: Alimentary Pharmacology & Therapeutics, Volume 15, Number 8, August 2001 , pp. 1187-1191(5)

Publisher: Blackwell Publishing

Abstract:

Background

: The cytoprotective agent, ecabet sodium, inhibits urease activity and growth of Helicobacter pylori. Aim

: To evaluate the efficacy and safety of ecabet sodium-based eradication of H. pylori infection, compared with a lansoprazole-based regimen, in a randomized multicentre study. Subjects and methods

: A total of 120 H. pylori-positive patients were assigned to one of two treatment regimens for 2 weeks: ecabet sodium 1 g b.d., amoxicillin 500 mg t.d.s. and clarithromycin 400 mg b.d. (EAC: 60 patients); or lansoprazole 30 mg (o.m.) with the same antimicrobial agents (LAC: 60 patients). Cure of infection was assessed by a ¹³C-urea breath test 1 month after completion of treatment. Results

: One patient in the EAC group and two in the LAC group did not complete therapy because of an adverse event, and three did not undergo the ¹³C-urea breath test. Cure rates for the intention-to-treat, all-patients-treated and per protocol analysis in the EAC group were 85%, 86% and 88%, respectively, whereas those in the LAC group were 85%, 88% and 91%. There were no significant differences in cure rate or adverse events between the two regimens. Conclusions

: Ecabet sodium in combination with amoxicillin and clarithromycin is as effective as lansoprazole-based eradication therapy for H. pylori.

Document Type: Research article

DOI: 10.1046/j.1365-2036.2001.01022.x

Affiliations: 1: Department of Internal Medicine II, Shimane Medical University, Izumo, Japan 2: Unnan General Hospital, Ohhara-gun, Japan 3: Shimane Environment & Health public Corporation, Shimane Adult Disease Center, Hamada, Japan

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Efficacy of ecabet sodium for Helicobacter pylori eradication triple therapy in comparison with a lansoprazole-based regimen