IngentaConnect There are some benefits for eradicating Helicobacter pylori in pa...

Authors: Des Varannes, S. Bruley¹; Fléjou, J. F.²; Colin, R.³; Zaïm, M.⁴; Meunier, A.⁴; Bidaut-Mazel, C.⁴

Source: Alimentary Pharmacology & Therapeutics, Volume 15, Number 8, August 2001 , pp. 1177-1185(9)

Abstract:

Background

: The relationship between Helicobacter pylori infection and non-ulcer dyspepsia is not established. Aim

: To determine whether eradication of H. pylori might be of benefit in non-ulcer dyspepsia patients. Methods

: We randomly assigned 129 H. pylori infected patients with severe epigastric pain, without gastro-oesophageal reflux symptoms, to receive twice daily treatment with 300 mg of ranitidine, 1000 mg of amoxicillin, and 500 mg of clarithromycin for 7 days and 124 such patients to receive identical-appearing placebos. Results

: Treatment was successful (decrease of symptoms at 12 months) in 62% of patients in the active-treatment group and in 60% of the placebo group (N.S.). At 12 months, the rate of eradication of H. pylori was 69% in the active-treatment group and 18% in the placebo group (P < 0.001). Complete relief of symptoms occurred significantly more frequently in patients on the active treatment (43%) than in placebo-treated patients (31%, P=0.048). Within the active-treatment group, therapeutic success was significantly more frequent in the non-infected patients (84% vs. 64%, P=0.04). Conclusions

: Although eradicating H. pylori is not likely to relieve symptoms in the majority of patients with non-ulcer dyspepsia, a small proportion of H. pylori-infected patients may benefit from eradication treatment.

Document Type: Research article

DOI: 10.1046/j.1365-2036.2001.01014.x

Affiliations: 1: Department of Hépato-Gastroentérologie, CHU de Nantes, Nantes, France 2: Department of Anatomie Pathologique, Hôpital St Antoine, Paris, France 3: Department of Hépato-Gastroentérologie, Hôpital Charles Nicolle, Rouen, France 4: Glaxo Wellcome, Marly le Roi, France

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There are some benefits for eradicating Helicobacter pylori in patients with non-ulcer dyspepsia