IngentaConnect The effect of cisapride on dyspepsia symptoms and the electrogast...

Authors: Besherdas¹; Leahy¹; Mason¹; Harbord¹; Epstein¹

Source: Alimentary Pharmacology & Therapeutics, Volume 12, Number 8, August 1998 , pp. 755-759(5)

Abstract:

Background:

The electrogastrogram (EGG), which records gastric myoelectrical activity, is abnormal in one-third of adult patients with non-ulcer dyspepsia (NUD). Aim:

To observe the effects of cisapride on EGG in adults with NUD. Methods:

Twenty-seven NUD patients who had undergone a pre- and post-prandial EGG were entered into an open study. All patients completed a dyspepsia symptom questionnaire and were then treated with cisapride 10 mg t.d.s. The dyspepsia questionnaire was repeated in all those completing 4 weeks of treatment. Those with an initial abnormal EGG (< 70% of slow wave activity at 2-4 cycles per minute) had a repeat EGG at the end of the study. Results:

Treatment with cisapride was associated with a significant improvement in the post-prandial EGG (P = 0.007). After 4 weeks of treatment, 7 of 13 abnormal EGGs normalized. Symptom scores improved significantly in the 13 patients with an abnormal EGG who completed treatment (P < 0.0003), but not in NUD patients with a normal EGG (P = 0.48). Conclusion:

In this open study, treatment of NUD with cisapride was associated with significant symptom improvement in patients with an abnormal pre-treatment EGG, but not those with a normal EGG, with a significant improvement of the post-prandial EGG.

Document Type: Original article

DOI: 10.1046/j.1365-2036.1998.00369.x

Affiliations: 1: Centre for Gastroenterology, Department of Medicine, Royal Free Hospital School of Medicine, London, UK

You have access to the full text article on a website external to Ingentaconnect.

Please click here to view this article on InterScience.

You may be required to register and activate access on InterScience before you can obtain the full text. If you have any queries please contact onlinehelp@oxon.blackwellpublishing.com

The effect of cisapride on dyspepsia symptoms and the electrogastrogram in patients with non-ulcer dyspepsia