IngentaConnect One-week use of ranitidine bismuth citrate, amoxycillin and clari...

Authors: Sung¹; Leung¹; Ling²; Yung³; Chan¹; Lee¹; Cheng²; Chung³

Source: Alimentary Pharmacology & Therapeutics, Volume 12, Number 8, August 1998 , pp. 725-730(6)

Abstract:

Background:

Proton pump inhibitors have been widely used in combination with amoxycillin, clarithromycin or metronidazole for the treatment of Helicobacter pylori infection. Aim:

To study the effects of 1-week ranitidine bismuth citrate (RBC)-based triple therapy in the treatment of H. pylori-related duodenal ulcers. Method:

Patients with duodenal ulcers and H. pylori infection were prospectively randomized to receive either RBC with amoxycillin and clarithromycin for 1 week (RAC), or omeprazole with amoxycillin and clarithromycin for 1 week (OAC). No additional ulcer healing drug was used after the 1-week medication. Patients were assessed for H. pylori eradication, ulcer healing and side-effects after receiving the therapies. Results:

One hundred consecutive patients were recruited to this study, with 50 patients randomized to each treatment group. In the intention-to-treat analysis, duodenal ulcers were completely healed in 45 (90%) patients in the RAC group and 43 (89.6%) in the OAC group (P = 1.0). H. pylori eradication was confirmed in 47 (94%) in the RAC group and 42 (87.5%) in the OAC group (P = 0.31). There was no significant difference in the severity of side-effects experienced by the two treatment groups. Conclusion:

One-week RBC-based triple therapy is an effective treatment for H. pylori-related duodenal ulcers. The therapeutic effects are comparable to a 1-week course of proton pump inhibitor-based triple therapy.

Document Type: Original article

DOI: 10.1046/j.1365-2036.1998.00367.x

Affiliations: 1: Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China, 2: Department of Microbiology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China, 3: Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China

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One-week use of ranitidine bismuth citrate, amoxycillin and clarithromycin for the treatment of Helicobacter pylori-related duodenal ulcer