IngentaConnect Substrate utilization in sea level residents during exercise in a...

Authors: Lundby, C.¹; Van Hall, G.¹

Source: Acta Physiologica, Volume 176, Number 3, November 2002 , pp. 195-201(7)

Abstract:

To investigate the effect of acclimatization to hypoxia on substrate utilization, eight sea level residents were studied during exercise at the same relative (rel) and absolute (abs) work rate as at sea level (SL), under acute (AH), and after 4 weeks exposure to 4100 m altitude (CH). Carbohydrate (CHO) and fat oxidation during exercise at SL were 2.0 ± 0.2 and 0.3 ± 0.0 g min⁻¹, respectively. At AH_abs and CH_abs CHO oxidation increased (P < 0.05) to 2.5 ± 0.2 and 2.3 ± 0.1 for CHO, and fat oxidation decreased (P < 0.05) to 0.2 ± 0.01 and 0.2 ± 0.01 g min⁻¹, respectively. Exercise in AH_rel and CH_rel did not cause a change in the relative CHO and fat oxidation compared with SL, the absolute rate of CHO oxidized being 1.7 ± 0.1 and 1.7 ± 0.02 g min⁻¹, respectively, and fat oxidation was 0.2 ± 0.02 g min⁻¹ in AC_rel and 0.3 ± 0.02 g min⁻¹ in CH_rel. In conclusion, substrate utilization is unaffected by AH and CH, when the work rate is matched to the same relative intensity as at SL.

Keywords: altitude; carbohydrate; catecholamines; fat; intensity; lactate; metabolism

Document Type: Research article

DOI: 10.1046/j.1365-201X.2002.01030.x

Affiliations: 1: The Copenhagen Muscle Research Centre, Copenhagen Ø, Denmark

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Substrate utilization in sea level residents during exercise in acute hypoxia and after 4 weeks of acclimatization to 4100 m