Effects of moderate and intensive training on functional activity of central 5-HT1B receptors in the rat substantia nigra
Authors: SEGUIN1; LISCIA2; GUEZENNEC2; FILLION1
Source: Acta Physiologica, Volume 162, Number 1, January 1998 , pp. 63-68(6)
Publisher: Blackwell Publishing
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Abstract:
The efficacy of the selective 5-HT1B receptor agonist CP 93,129 in inhibiting the forskolin-stimulated adenylyl cyclase activity in the rat substantia nigra was reduced by both moderate and intensive prolonged training compared with sedentary resting rats. The concentration-response curves of the agonist were shifted to the right with a sixfold increase of the half-maximal inhibitory concentration. A difference was observed between the two training exercises in regard to further changes in 5-HT1B receptor sensitivity induced by an acute restraint stress. This manipulation did not affect the functional response of the 5-HT1B receptors further in moderately trained rats, whereas an additional desensitization of the 5-HT1B receptors was observed in intensively trained rats. These results strongly suggest the existence of regulation mechanisms altering the functional efficacy of 5-HT1B receptors and, accordingly, affecting the serotonergic activity, since 5-HT1B receptors modulate the neuronal release of the amine.Keywords: adenylyl cyclase activity; CP 93,129; desensitization; 5-HT1B receptors; physical exercise; rat; restraint stress; substantia nigra
Document Type: Original article
DOI: 10.1046/j.1365-201X.1998.0270f.x
Affiliations: 1: Unité de Pharmacologie Neuro-Immuno-Endocrinienne, Institut Pasteur, Paris 2: Département de Neurophysiologie Appliquée, IMASSA-CERMA, Brétigny-sur-Orge, France
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