IngentaConnect HIV entry inhibitors: a new generation of antiretroviral drugs

Authors: KRAMBOVITIS, Elias¹; PORICHIS, Filippos¹; SPANDIDOS, Demetrios A²

Source: Acta Pharmacologica Sinica, Volume 26, Number 10, October 2005 , pp. 1165-1173(9)

Abstract:

AIDS is presently treatable, and patients can have a good prognosis due to the success of highly active antiretroviral therapy (HAART), but it is still not curable or preventable. High toxicity of HAART, and the emergence of drug resistance add to the imperative to continue research into new strategies and interventions. Considerable progress in the understanding of HIV attachment and entry into host cells has suggested new possibilities for rationally designing agents that interfere with this process. The approval and introduction of the fusion inhibitor enfuvirtide (Fuzeon) for clinical use signals a new era in AIDS therapeutics. Here we review the crucial steps the virus uses to achieve cell entry, which merit attention as potential targets, and the compounds at pre-clinical and clinical development stages, reported to effectively inhibit cell entry.

Keywords: highly active antiretroviral therapy; HIV receptors; HIV fusion inhibitors; HIV

Document Type: Research article

DOI: 10.1111/j.1745-7254.2005.00193.x

Affiliations: 1: Department of Applied Biochemistry and Immunology, Institute of Molecular Biology and Biotechnology, Vassilika Vouton, Heraklion, Crete, Greece; 2: Greece Department of Virology, Medical School, University of Crete, Heraklion, Crete, Greece

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