Treatment of Full-thickness Skin Defect with Concomitant Grafting of 6-fold Extended Mesh Auto-skin and Allogeneic Cultured Dermal Substitute
Authors: Naohiro Kashiwa1; Osamu Ito1; Takeshige Ueda1; Kentaro Kubo2; Hiromichi Matsui2; Yoshimitsu Kuroyanagi
Source: Artificial Organs, Volume 28, Number 5, May 2004 , pp. 444-450(7)
Publisher: Blackwell Publishing
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Abstract:
: The aim of this clinical study was to evaluate an allogeneic cultured dermal substitute (CDS) as a biological dressing for highly extended mesh auto-skin grafting. The subjects were five patients with extensive deep burn wounds. Allogeneic CDS was prepared by seeding fibroblasts on a spongy matrix of hyaluronic acid and atelo-collagen. Six-fold extended auto-skin graft was applied to the debrided wound, on which allogeneic CDS was placed. A conventional ointment-gauze dressing was used to protect the CDS. The CDS was applied repeatedly at intervals of 5–7 days. In all cases, the wounds were closed by successful take of mesh auto-skin graft and prompt epithelization from the grafted skin. The skin on the grafted area had a cicatrix appearance, but was soft and thin, maintaining good quality. The application of 6-fold extended auto-skin graft in conjunction with allogeneic CDS is an effective method for treatment of extensive severe burn wounds.Keywords: Cultured dermal substitute; Fibroblasts; Hyaluronic acid; Collagen; Mesh skin grafting
Document Type: Research article
DOI: 10.1111/j.1525-1594.2004.00009.x
Affiliations: 1: Department of Plastic and Reconstructive Surgery, Kagawa Prefectural Central Hospital, Takamatsu, Kagawa 2: R&D Center for Artificial Skin, School of Allied Health Sciences, Kitasato University, Sagamihara, Kanagawa, Japan
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