Environmental exposure to dioxin: the Seveso experience

Authors: Signorini, S.¹; Gerthoux, P. M.¹; Dassi, C.¹; Cazzaniga, M.¹; Brambilla, P.¹; Vincoli, N.¹; Mocarelli, P.¹

Source: Andrologia, Volume 32, Numbers 4-5, September 2000 , pp. 263-270(8)

Publisher: Blackwell Publishing

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Abstract:

The toxicity in humans of 2,3,7,8-tetrachlorodibenzo-p-dioxin, a man-made compound and environmental pollutant, is still debated. The industrial accident at Seveso, Italy, in 1976 exposed a large population of both sexes and of all ages to a massive concentration of 2,3,7,8-tetrachlorodibenzo-p-dioxin. Monitoring of soil and measurement of blood samples allowed classification of the exposed population into three categories: A, B and R (high, medium and low exposure, respectively). This article presents data from longitudinal health monitoring of the population, including liver function, immune function, neurological impairment, dermatological effects, reproductive pathology, and mortality.

Keywords: Environmental pollutants; uman health; eproductive pathology; ex ratio; CDD

Document Type: Research article

DOI: 10.1046/j.1439-0272.2000.00394.x

Affiliations: 1: Department of Laboratory Medicine, University of Milano-Bicocca, Hospital of Desio, Desio, Milan, Italy

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