IngentaConnect Xenobiotic metabolism, genetic polymorphisms and male infertility

Authors: Schuppe, H.-C.¹; Wieneke, P.²; Donat, S.²; Fritsche, E.²; Köhn, F.-M.³; Abel, J.²

Source: Andrologia, Volume 32, Numbers 4-5, September 2000 , pp. 255-262(8)

Abstract:

Male reproductive function may be impaired by various occupational and environmental chemical agents. The majority of these xenobiotics, however, require metabolic activation in order to exert adverse effects via covalent interactions between intermediate metabolites and cellular macromolecules such as DNA or protein. In addition, metabolization may alter endocrine-disrupting properties of xenobiotics. Thus tissue-specific expression and regulation of multiple xenobiotic-metabolizing enzymes are likely to play an important role in chemically induced disorders of male reproductive organs. Recent studies suggest that genetic polymorphisms underlying inter-individual and inter-ethnic variability of xenobiotic metabolism modulate susceptibility to male reproductive disorders. For cytochrome P450 1A1 (CYP1A1), a key enzyme in extra-hepatic metabolic activation of lipophilic xenobiotics, increased frequencies of two genetically linked polymorphisms have been found among infertile men.

Keywords: Cytochrome P450; ale infertility; ale reproductive tract; olymorphism; enobiotic metabolism

Document Type: Research article

DOI: 10.1046/j.1439-0272.2000.00393.x

Affiliations: 1: Andrology Unit, Department of Dermatology, Heinrich Heine University, Düsseldorf, Germany; 2: Division of Toxicology, Medical Institute of Environmental Hygiene, Düsseldorf, Germany; 3: Department of Dermatology, Technical University, Munich, Germany

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