IngentaConnect The effect of dilution and prolonged injection time on fentanyl-i...

Authors: Yu, H.¹; Yang, X.-Y.²; Zhang, X.¹; Li, Q.¹; Zhu, T.³; Wang, Y.³; Liu, B.⁴

Source: Anaesthesia, Volume 62, Number 9, September 2007 , pp. 919-922(4)

Abstract:

Summary

This study was designed to evaluate the effect of diluting fentanyl 50 μg.ml⁻¹ to 25 or 10 μg.ml⁻¹ with 0.9% saline and prolonged injection time on fentanyl-induced cough. Two hundred patients requiring general anaesthesia were randomly allocated into four groups: 50 μg.ml⁻¹ (Group I), 25 μg.ml⁻¹ (Group II), 10 μg.ml⁻¹ (Group III) or 10 μg.ml⁻¹ combined with prolonged injection (Group IV). Fentanyl 3 μg.kg⁻¹ was administered within 5 s in Groups I, II, and III, or over 30 s in Group IV. Occurrence of cough was significantly reduced in Group IV (2% vs 32%, 16% and 12% in Groups I, II and III, respectively, p < 0.05). There were no statistically significant differences in the severity of coughing between the four groups (p > 0.05). We conclude that dilution of fentanyl to 10 μg.ml⁻¹ with 0.9% saline combined with a prolonged injection time eliminates fentanyl-induced cough.

Document Type: Research article

DOI: 10.1111/j.1365-2044.2007.05147.x

Affiliations: 1: Attending 2: Attending, Department of Obstetrics and Gynecology, West China Second Hospital, Sichuan University, Chengdu, Sichuan 610041, People's Republic of China 3: Associate Professor 4: Professor, Department of Anaesthesiology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, People's Republic of China

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The effect of dilution and prolonged injection time on fentanyl-induced coughing