IngentaConnect A minimally invasive metabolic test with intramuscular injection ...

Authors: Schuster, F.¹; Gardill, A.²; Metterlein, T.¹; Kranke, P.³; Roewer, N.⁴; Anetseder, M.³

Source: Anaesthesia, Volume 62, Number 9, September 2007 , pp. 882-887(6)

Abstract:

Summary

We hypothesised that intramuscular halothane injection increases local Pco₂ concentrations in malignant hyperthermia susceptible (MHS) but not in non-susceptible (MHN) individuals. Pco₂ probes with attached microtubing catheters for halothane injection were placed into the lateral vastus muscle of eight MHS and eight MHN probands. Following equilibration, a single bolus of 200 μl halothane 5 and 6 vol% was injected. Pco₂ was measured spectrophotometrically. Baseline Pco₂ concentrations were similar between groups. Maximum Pco₂ and maximum rate of Pco₂ increase was significantly enhanced by halothane 5 and 6 vol% in MHS compared to MHN probands. Systemic haemodynamic and metabolic parameters did not differ between both groups. Local halothane application induces a hypermetabolic reaction with a significant Pco₂ increase in MHS compared to MHN probands, indicating a susceptibility to malignant hyperthermia. Intramuscular halothane injection with Pco₂ measurement seems to be a suitable method for the development of a minimally invasive metabolic test to diagnose malignant hyperthermia susceptibility.

Document Type: Research article

DOI: 10.1111/j.1365-2044.2007.05173.x

Affiliations: 1: Resident 2: Medical student 3: Staff Anaesthetist 4: Professor and Chair, University of Würzburg, Department of Anaesthesiology, Oberdürrbacher Straße 6, D-97080 Würzburg, Germany

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A minimally invasive metabolic test with intramuscular injection of halothane 5 and 6 vol% to detect probands at risk for malignant hyperthermia