IngentaConnect The utility of B-type natriuretic peptide in predicting postopera...

Authors: Cuthbertson, B. H.¹; Card, G.²; Croal, B. L.³; McNeilly, J.⁴; Hillis, G. S.⁵

Source: Anaesthesia, Volume 62, Number 9, September 2007 , pp. 875-881(7)

Abstract:

Summary

B-type natriuretic peptide (BNP) levels predict cardiovascular risk in several settings. We hypothesised that they would identify individuals at increased risk of complications and mortality following major emergency non-cardiac surgery. Forty patients were studied with a primary end-point of a new postoperative cardiac event, and/or development of significant ECG changes, and/or cardiac death. The main secondary outcome was all-cause mortality at 6 months. Pre-operative BNP levels were higher in 11 patients who suffered a new postoperative cardiac event (p = 0.001) and predicted this outcome with an area under the receiver operating characteristic curve of 0.85 (CI = 0.72-0.98, p = 0.001). A pre-operative BNP value > 170 pg.ml⁻¹ has a sensitivity of 82% and a specificity of 79% for the primary end-point. In this small study, pre-operative BNP levels identify patients undergoing major emergency non-cardiac surgery who are at increased risk of early postoperative cardiac events. Larger studies are required to confirm these data.

Document Type: Research article

DOI: 10.1111/j.1365-2044.2007.05146.x

Affiliations: 1: Clinical Senior Lecturer 2: Research Student, Health Services Research Unit, University of Aberdeen 3: Consultant 4: Research Fellow, Department of Clinical Biochemistry, Aberdeen Royal Infirmary 5: Clinical Senior Lecturer, Department of Cardiology, University of Aberdeen, Aberdeen, Scotland AB25 2ZD, UK

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The utility of B-type natriuretic peptide in predicting postoperative cardiac events and mortality in patients undergoing major emergency non-cardiac surgery