IngentaConnect Efficacy of Enteral Nutrition for the Treatment of Pancreatitis U...

Authors: Makola, Diklar¹; Krenitsky, Joe¹; Parrish, Carol¹; Dunston, Emily¹; Shaffer, Hubert A²; Yeaton, Paul¹; Kahaleh, Michel¹

Source: The American Journal of Gastroenterology, Volume 101, Number 10, October 2006 , pp. 2347-2355(9)

Publisher: Blackwell Publishing

Abstract:

BACKGROUND AND AIMS: Elemental formula delivered distal to the ligament of Treitz has demonstrated efficacy in patients with pancreatitis, presumably by decreasing pancreatic stimulation. Few data exist on the use of standard enteral formula in such patients. This study describes the outcomes of pancreatitis patients managed with long-term standard enteral nutrition (EN).

METHODS: One hundred twenty-six patients managed at the University of Virginia Health System with pancreatitis requiring nutritional support between August 2000 and June 2004 received a standard formula delivered distal to the ligament of Treitz and were followed prospectively to resolution of their disease process. Predictors of improvement in CT Severity Index, duration of EN, and length of hospital stay were identified. Changes in body weight and serum albumin were determined.

RESULTS: Mean age was 50.8 ± 15.2 yr (male, 83). Etiology included alcohol (46), gallstones (49), idiopathic (15), post-ERCP (7), drug (5), hyperlipidemia (3), and pancreas divisum (1). EN lasted a median of 18.9 (2.4 to 111.7) wk. Median CT Severity Index decreased from 4 to 2 (p < 0.001). Underweight patients gained 9.8 lbs; overweight and obese patients lost 7.2 and 28.8 lbs, respectively. Albumin concentration increased from 3 to 3.8 g/dL (p < 0.001).

CONCLUSIONS: Standard enteral formula is effective in the management of patients with complicated pancreatitis.

(Am J Gastroenterol 2006;101:2347-2355)

Document Type: Research article

DOI: 10.1111/j.1572-0241.2006.00779.x

Affiliations: 1: Digestive Health Center, University of Virginia Health System, Charlottesville, Virginia 2: Department of Radiology, University of Virginia Health System, Charlottesville, Virginia

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Efficacy of Enteral Nutrition for the Treatment of Pancreatitis Using Standard Enteral Formula