IngentaConnect Treatment of Helicobacter pylori in patients with duodenal ulcer ...

Authors: Lai K.-C.,¹; Hui, W.; Wong, W.; Wong, B.C.; Hu, W.H.C.; Ching, C.; Lam, S.

Source: The American Journal of Gastroenterology, Volume 95, Number 9, 1 September 2000 , pp. 2225-2232(8)

Abstract:

OBJECTIVE:Eradication of Helicobacter pylori (H. pylori) in patients with uncomplicated duodenal ulcers prevents long-term recurrence of ulcers. We aimed to study whether treatment of H. pylori prevents the long-term recurrence of duodenal ulcer hemorrhage.METHODS:Patients with duodenal ulcer bleeding and confirmed H. pylori infection were recruited. A total of 120 patients were randomly assigned to triple therapy (DeNoltab 120 mg, amoxycillin 500 mg, and metronidazole 300 mg four times daily) or DeNoltab 120 mg four times daily alone. No maintenance therapy was given during the follow-up period. The endpoints were the cumulative rates of symptomatic and bleeding duodenal ulcer recurrences.RESULTS:Of the patients receiving the triple regimen, 85.1% had H. pylori eradicated as compared to 2.0% of patients receiving DeNoltab (p < 0.05). More patients in the DeNoltab group than those in the Triple group had recurrence of ulcer bleeding, but this did not reach statistical significance (12/60 vs 6/60, p = 0.20). Logistic regression analysis on clinical, personal, and endoscopic characteristics identified persistent H. pylori infection as the only independent predictor of recurrence of duodenal ulcer bleeding.CONCLUSIONS:Treatment of H. pylori alone with the present bismuth-based triple therapy in patients with duodenal ulcer hemorrhage did not result in significant reduction in further bleeding episodes, although a trend was seen for the group that was given triple therapy. On the other hand, posttreatment H. pylori status was found to be an independent predictor of bleeding recurrence.

Document Type: Research article

DOI: 10.1016/S0002-9270(00)01041-8

Affiliations: 1: aDepartment of Medicine, University of Hong Kong, Queen Mary Hospital, Pokfulam, , Hong Kong, China

Treatment of Helicobacter pylori in patients with duodenal ulcer hemorrhage- a long-term randomized, controlled study