IngentaConnect Comparative Studies on the Distribution of Glutamate Transporters...

Authors: Kang, T.-C.¹; Park, S.-K.¹; Jo, S. M.¹; Lee, J.-Y.²; Won, M. H.¹; Park, J.³; Choi, S. Y.

Source: Anatomia, Histologia, Embryologia, Volume 29, Number 6, December 2000 , pp. 381-383(3)

Abstract:

Summary

Glutamate is the major excitatory amino acid transmitter in vertebrate retinae. Glutamate transporters therefore play an important role in the precise control of glutamate concentration in the synaptic cleft by regulating extracellular glutamate concentration. In the present study, we performed an analysis of the expressions of three glutamate transporters in gerbil retina using immunohistochemistry. In the gerbil retina, excitatory amino acid carrier 1 and glutamate transporter 1 immunoreactivity was predominant in the ganglion cells but not amacrine or bipolar cells. Glutamate/aspartate transporter (GLAST) immunoreactivity was observed in the radial gliocytes of which the dense network of fine processes was localized in the inner and outer plexiform layers. GLAST immunoreactivity was also detected in astrocytes in the nerve fibre layer. These results demonstrate that three glutamate transporters show specific distributions in the gerbil retina and suggest that the glutamate re-uptake system in the gerbil retina may be different from that of the rat.

Document Type: Research article

Affiliations: 1: Departments of Anatomy and 2: Biochemistry, College of Medicine, and 3: Department of Genetic Engineering, Division of Life Science, Hallym University, Chunchon 200-702, South Korea;

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Comparative Studies on the Distribution of Glutamate Transporters in the Retinae of the Mongolian Gerbil and the Rat