IngentaConnect Brain Natriuretic Peptide and N-Terminal Pro-B-Type Natriuretic P...

Authors: Di Somma, Salvatore¹; Magrini, Laura¹; Tabacco, Fabio²; Marino, Rossella¹; Talucci, Veronica¹; Marrocco, Francesca¹; Cardelli, Patrizia²; Ferri, Enrico¹; Pittoni, Valerio¹

Source: Congestive Heart Failure, Volume 14, Number 5, September/October 2008 , pp. 245-250(6)

Publisher: Blackwell Publishing

Abstract:

Brain natriuretic peptide (BNP) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) are currently used for the diagnosis, prognosis, and therapeutic decision making in heart failure patients. The aim of the study was to compare BNP and NT-proBNP plasma concentration profiles in 42 patients with decompensated heart failure who underwent treatment in the emergency department. A significant decrease in both peptide concentrations fell beyond 24 hours of therapy. BNP concentration underwent a more responsive change from admission (−54.1%±8.6% at 72 hours and −57.4%±7.6% at discharge) than NT-proBNP concentration (−17.6%±5.4% at 72 hours and −18.6%±5.6% at discharge). Although BNP and NT-proBNP concentrations were highly correlated, no correlation in their variations was found, a finding that suggests a different kinetic behavior in response to treatment. Sequential measurements of BNP and NT-proBNP provide a reliable marker to confirm clinical improvement after 24 hours of treatment. BNP may show some advantages over NT-proBNP as a more sensitive marker of early stabilization in response to therapy. Congest Heart Fail. 2008;14:245-250. ^©2008 Le Jacq

Document Type: Research article

DOI: 10.1111/j.1751-7133.2008.00002.x

Affiliations: 1: From the Emergency Medicine Department, 2: Cellular Biotechnologies and Hematology Department, II Medical School University “La Sapienza,” Sant'Andrea Hospital, Rome, Italy

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Brain Natriuretic Peptide and N-Terminal Pro-B-Type Natriuretic Peptide Show a Different Profile in Response to Acute Decompensated Heart Failure Treatment