IngentaConnect Microalbuminuria in Nondiabetic and Nonhypertensive Systolic Hear...

Authors: Figueiredo, Estêvão L.¹; Leão, Fabiana V.G.²; Oliveira, Lílian V.²; Moreira, Maria C.V.³; Figueiredo, Amintas F.S.²

Source: Congestive Heart Failure, Volume 14, Number 5, September/October 2008 , pp. 234-238(5)

Publisher: Blackwell Publishing

Abstract:

The American Diabetes Association and the National Kidney Foundation define microalbuminuria as an albumin (μg)/creatinine (mg) ratio (ACR) between 30 and 300 μg/mg regardless of sex. Microalbuminuria is associated with increased cardiovascular risk. The authors evaluated the prevalence of microalbuminuria in nondiabetic and nonhypertensive systolic heart failure (SHF) patients. Twenty-seven SHF patients, 18 years and older, with New York Heart Association functional classes II through IV and left ventricular ejection fraction ≤40%, who were nondiabetic and nonhypertensive and not receiving angiotensin-converting enzyme inhibitors, were selected. Twenty-seven healthy individuals, paired according to sex, ethnicity, and age, were used as controls. Early-morning midstream urine was used. Data are expressed as medians. Excretion of albumin in SHF patients (39 μg/mL urine) was significantly higher than in controls (26 μg/mL urine). Creatinine excretion was not significantly different between patients and controls. ACR was significantly higher in patients (54 μg/mg) than in controls (24 μg/mg). The results indicate that microalbuminuria was significantly present in nondiabetic and nonhypertensive SHF patients. Congest Heart Fail. 2008;14:234-238. ^©2008 Le Jacq

Document Type: Research article

DOI: 10.1111/j.1751-7133.2008.00008.x

Affiliations: 1: From the Programa de Pós-graduação em Clínica Médica, Faculdade de Medicina, Universidade Federal de Minas Gerais (UFMG), and Arcelor-Mittal Abeb and Hospital Life Center, 2: the Departamento de Análises Clínicas e Toxicológicas, Faculdade de Farmácia, UFMG, 3: the Departamento de Clínica Médica, Faculdade de Medicina, UFMG, Belo Horizonte, MG, Brazil

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Microalbuminuria in Nondiabetic and Nonhypertensive Systolic Heart Failure Patients