IngentaConnect Sanguinarine

Authors: Mackraj, I.¹; Govender, Thirumala²; Gathiram, Prem³

Source: Cardiovascular Drug Reviews, Volume 26, Number 1, Spring 2008 , pp. 75-83(9)

Abstract:

Sanguinarine is an alkaloid found in many medicinal plants. It has diverse biological activities, including modulation of nuclear factor-κB and of several enzymes. It is also known to induce apoptosis, perturb microtubules, and to have antimicrobial effects. This article reviews its cardiovascular properties, including hypotensive, antiplatelet, and positive inotropic effects. Its pharmacokinetics, and toxicology, including its carcinogenic potential, are also discussed. Further pharmacological and toxicological studies with sanguinarine are needed before its therapeutic use can be considered.

Keywords: AT1 receptor blockers; Antihypertensive drugs; Antiplatelet drugs; Sanguinarine

Document Type: Research article

DOI: 10.1111/j.1527-3466.2007.00037.x

Affiliations: 1: Department of Human Physiology 2: School of Pharmacy 3: Family Medicine, Nelson R. Mandela School of Medicine, University of KwaZulu, Durban, South Africa

You have access to the full text article on a website external to Ingentaconnect.

Please click here to view this article on InterScience.

You may be required to register and activate access on InterScience before you can obtain the full text. If you have any queries please contact onlinehelp@oxon.blackwellpublishing.com