A Century of Biometrical Genetics

Authors: Elston, Robert C.1; Thompson, Elizabeth A.2

Source: Biometrics, Volume 56, Number 3, September 2000 , pp. 659-666(8)

Publisher: Blackwell Publishing

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Abstract:

Summary.

We briefly review the major contribution of biometrics to genetics over the last century (population genetic models, familial correlations, segregation analysis, and gene mapping) and current areas of active research and then speculate about what problems will be tackled in the next century.

Keywords: Familial correlations; Gene mapping; Population genetic models; Segregation analysis

Document Type: Research article

DOI: 10.1111/j.0006-341X.2000.00659.x

Affiliations: 1: Department of Epidemiology and Biostatistics, Case Western Reserve University, 2500 Metro Health Drive, Rammelkamp 258, Cleveland, Ohio 44109, U.S.A., Email: rce@darwin.cwru.edu 2: Department of Statistics, University of Washington, Box 354322, Seattle, Washington 98195, U.S.A.

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