IngentaConnect Calcifying tissue of florid cemento-osseous dysplasia easily invo...

Authors: Park, In Woo¹; Choi, Hang Moon¹; Park, Young Wook²; Kim, Soung Min²; Kim, Ji Hyuck²; Huh, Jin Young³; Park, Yang Soon⁴; Lee, Young Joon⁵; Lee, Sang Shin⁵; Lee, Suk Keun⁵

Source: Basic and Applied Pathology, Volume 1, Number 2, June 2008 , pp. 107-109(3)

Publisher: Blackwell Publishing

Abstract:

Florid cemento-osseous dysplasia (FCOD) is a benign, non-neoplastic lesion characterized by multiple sclerosing masses only within jawbones. It is frequently confused with chronic diffuse sclerosing osteomyelitis (CDSO) in the literature. Two cases of FCOD are examined to determine the characteristics of their calcifying tissues. The first case was non-infected, while the second case was severely infected, displaying the typical features of CDSO in clinico-radiologic findings. The infected FCOD case showed large bacterial colonies in the main lesion with rare inflammatory reaction. The globular cementum-like materials of FCOD looked like woven bone and showed increased positive reaction to Alcian blue stain, of which peripheral margin was strongly positive for the antibody of ameloblastin, and weakly positive for the antibodies of bone morphogenetic protein-2 and -4. In the immunostains of matrix metalloprotein-3, -9, -10, and transforming growth factor-alpha, macrophage infiltration in the FCOD lesion were rarely observed. These data suggest that the cementum-like materials of FCOD contain various matrix proteins, and that the cementum-like materials are relevant to the overgrowth of the bacterial colonies by the inhibition of regional inflammatory reactions.

Keywords: chronic diffuse sclerosing osteomyelitis (CDSO); florid cemento-osseous dysplasia (FCOD); immunohistochemistry

Document Type: Case report

DOI: 10.1111/j.1755-9294.2008.00023.x

Affiliations: 1: Department of Oral and Maxillofacial Radiology 2: Department of Oral and Maxillofacial Surgery 3: Department of Dentistry 4: Department of Pathology, Asan Gangneung Hospital, Gangneung, Korea 5: Department of Oral Pathology, College of Dentistry, Kangnung National University

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Calcifying tissue of florid cemento-osseous dysplasia easily involving chronic diffuse sclerosing osteomyelitis