IngentaConnect Immunohistological study of skin involvement in Kikuchi's disease

Authors: Lee, Hyekyung¹; Oh, Shintaek²; Kim, Myungsuk³; Shin, Soyoung⁴; Park, Meeja¹

Source: Basic and Applied Pathology, Volume 1, Number 2, June 2008 , pp. 98-101(4)

Abstract:

We describe the immunohistochemical findings of the skin lesion of Kikuchi's disease (KD) in two patients. They presented with fever, lymphadenopathy, and eruptions on the skin of palm and face. Each patient had a lymph node biopsy which showed the typical necrotizing lymphadenitis of KD. Skin biopsies from the two patients showed various pathologic findings of a crusted epidermis, a dense lymphohistiocytic perivascular and interstitial infiltrate, and abundant karyorrhectic debris with an absence of neutrophils, paralleling the nodal histology in KD. Immunohistochemically, the lymphohistiocytic cells in the skin and lymph nodes showed similar positivity for CD68, CD3, CD8, granzyme B and negativity for CD20 and CD4. These findings suggest that the cytotoxic T lymphocytes play important roles in the skin and lymph node without the significant assistance of B and helper T lymphocytes.

Keywords: cutaneous Kikuchi's disease; immunohistochemistry

Document Type: Case report

DOI: 10.1111/j.1755-9294.2008.00024.x

Affiliations: 1: Department of Pathology, Eulji University, College of Medicine, Daejon 2: Dermatology 3: Internal Medicine 4: Laboratory Medicine, Daejon St. Mary's hospital, Catholic University, College of Medicine, Daejon, Korea

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