IngentaConnect Acute myelomonocytic leukaemia with short-term spontaneous remiss...

Authors: MYLONAKIS, ME¹; PETANIDES, TA¹; VALLI, VE²; VERNAU, W³; KOYTINAS, AF¹; MICHAEL, RS¹

Source: Australian Veterinary Journal, Volume 86, Number 6, June 2008 , pp. 224-228(5)

Abstract:

A 2-year-old, spayed female domestic shorthair cat was referred with a history of anorexia and depression of 1 week duration. On physical examination, the cat was lethargic and febrile, with splenomegaly, anisocoria and ulcerative stomatitis. A complete blood count (CBC) and a biochemistry profile showed leukocytosis, numerous blast cells in the peripheral blood, thrombocytopenia, hyperglobulinaemia and a positive test for feline leukaemia virus antigen. A diagnosis of acute myelomonocytic leukaemia was made on the basis of the results of bone marrow cytology, histopathology, and immunochemistry (CD3, CD79a, lysozyme, and myeloperoxidase) tests. Following an unexpected 1-month period of clinical and clinicopathological remission without chemotherapy, the cat relapsed and died 1 week later.

Aust Vet J 2008;86:224-228

Keywords: myeloid neoplasms; acute myelomonocytic leukaemia; cat

Document Type: Research article

DOI: 10.1111/j.1751-0813.2008.00304.x

Affiliations: 1: Companion Animal Clinic, Aristotle University of Thessaloniki, Greece;, Email: mmylonak@vet.auth.gr 2: Veterinary Diagnostic Laboratory, University of Illinois, USA 3: Department of Pathology, Microbiology and Immunology, University of California-Davis, USA

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Acute myelomonocytic leukaemia with short-term spontaneous remission in a cat